Why Migraine and Headache Treatment starts Before the Attack: The Power of the "Inter-Ictal" Phase of Migraine
- Wayne Elphinstone

- Jan 25
- 3 min read

Imagine waking up to the sound of a storm. Rain is pounding against your house, and suddenly, water starts dripping onto your bed. In a panic, you grab a bucket. You grab a towel. You might even climb up a ladder in the pouring rain to try and patch the hole.
It’s chaotic, it’s stressful, and frankly, it’s the worst possible time to do repair work.
Yet, this is exactly how most of us treat migraine. We wait for the "storm"—the pain, the nausea, the aura—and then we scramble for abortive medications, ice packs, and dark rooms. We spend our lives in "damage control" mode.
But
What if the key aspect of your migraine treatment isn't your actions during a headache, but rather what you do when you feel fine?
The "Silent" Phase of the Migraine Attack
In medical terms, the time between migraine attacks is called the Inter-Ictal Phase.
For years, doctors (and patients) viewed this phase as "normal." It was simply the break between the storms. But modern neuroscience has revealed a startling truth: The migraine brain never truly sleeps.
Even on your best, pain-free days, your brain is functioning differently than a non-migraine brain. It exists in a state of "altered sensory processing". It is constantly hyper-vigilant, scanning the environment for threats, and struggling to filter out sensory noise like bright lights or loud sounds.
Think of it like a phone running a dozen apps in the background. The screen might be off, but the battery is draining, and the processor is heating up.
Why Reactive Migraine and Headache Treatment Fails
Treating migraine only when the pain hits is like trying to fix a roof during a hurricane. The biological "noise" of the attack—the inflammation, the pain signaling, the vascular changes—is too loud. You can suppress the symptoms, but you cannot fix the underlying dysfunction.
This reactive approach leaves you stuck in a cycle of fear, waiting for the next attack to derail your life. This anxiety itself is known as the "inter-ictal burden," and it adds a heavy layer of stress that can actually lower your threshold for the next attack.
The Strategy: Building a Brain That Refuses to Crash
The "Beyond Migraine" philosophy is simple: Fix the roof while the sun is shining.
The inter-ictal phase is the "sensible period to intervene". It is the only time your brain is calm enough to actually heal. By shifting your focus to this phase, you stop chasing pain relief and start building physiological resilience.
This means using your good days to:
Stabilize Metabolism: preventing the "energy dips" that leave neurons starving.
Calm the Nervous System: actively retraining your brain to filter sensory input correctly.
Reduce Inflammation: lowering the baseline "noise" in your body so your brain doesn't feel under attack.
Reclaiming Your Life
When you intervene during the inter-ictal phase, you aren't just aborting a headache; you are raising your "Migraine Threshold." You are building a brain that is robust enough to handle a glass of wine, a late night, or a stressful deadline without crashing.
You stop being a victim of the storm and become the architect of your own health.
It’s time to put down the bucket and pick up the toolbox.
References
Ashina, S. et al. (2021). 'Structural and functional brain changes in migraine', Current Opinion in Neurology, 34(3), pp. 341-348.
Shin, J.H. et al. (2014). 'Altered brain metabolism in vestibular migraine: Comparison of interictal and ictal findings', Cephalalgia, 34(1), pp. 58-67.
Lipton, R.B. et al. (2014). 'Reduction in perceived stress as a migraine trigger: testing the "let-down headache" hypothesis', Neurology, 82(16), pp. 1395-1401.
Beyond Migraine Customer Bible. (2024). 'The Core Premise: The Inter-Ictal Phase




Comments